Note: Trades made from November 1, 2020 to March 1, 2021
- Shamrocks trade D Peralta to Assassins for B Singer
- Lumberjacks trade Y Moncada, A Haseley to Express for A Judge, E Suarez
- Shamrocks trade 2021 4 (Shamrocks) to Kiwis for A Duvall
- Shamrocks trade 2021 4 (Naturals) to Sluggers for S Choo
- Goats trade G Torres, A Riley, A Puk to Kiwis for M Machado, H Castro
- Goats trade M Moustakas to Assassins for T Skubel, F Alvarez
- Kiwis trade T La Stella, A Simmons to Naturals for 2021 1 (Naturals), 2021 3 (Naturals)
- Kiwis trade K Jansen, 2021 5 (Kiwis) to Shamrocks for N Senzel
- Sluggers trade M Stroman, M Harrison, 2022 5 (Sluggers) to Kiwis for M Muncy
- Goats trade Z Britton to Assassins for N Pearson
- Naturals trade 2021 2 (Naturals) to Condors for K Seager
- Goats trade 2021 6 (Cornfield), 2021 7 (Goats) to Condors CJ Cron, D Bote
- Dawgz trade 2021 10 (Dawgs) to Cornfield for J Gant
- Cornfield trade P De Leon, S Kingery to Kiwis for 2021 8 (Kiwis)
- Express trade C Kershaw, A Dickerson, J Bell, T d'Arnaud to Naturals for J Flaherty, T LaStella, B Reynolds, J Stallings
- Goats trade N Pearson, T Skubel, H Castro, 2022 1 (Goats), 2022 2 (Goats) to Grizzlies for D Bundy, M Tanaka, Y Petit
- Sluggers trade A Pujols to Grizzlies for 2021 9 (Grizzlies)
- Grizzlies trade 2021 4 (Grizzlies), 2021 7 (Grizzlies) to Goats for D Bote, 2022 3 (Goats)
- Goats trade 2021 10 (Goats) to Dawgz for K Smith
- Goats trade 2022 9 (Goats) to Express for K Yates
- Triplets trade their 2021 12 (Triplets) to Tigers for N. Hoerner
Note: Cuts below are official on March 1, 2021
- Assassins cut C McHugh, J Jiménez, R Stephenson, P Strop, H Strickland, C Iannetta, B McCann
- Condors cut M Beaty, R Chirinos, J Smith, G Heredia, I Nova
- Cornfield cut I Vargas, B Workman, T Richards, C Stammen, S Gaviglio, S Dyson, A Cashner
- Dawgz cut G Gonzalez, T Wingenter, M Wieters, H Perez, N Markakis, A Jones, A Hansen
- Express cut D Santana, T Skaggs, F Vazquez, E Encarnacion, B Holaday, R Stripling, A Morgan, J Bauers
- Gadflies cut E Thames, T Roark, J Osich, E Adrianza
- Goats cut H Robles, B Brennan, K Giles, H Kendrick, D Freese
- Grizzlies cut R Quinn, I Desmond, J Phegley, M Hanover, C Stewart, J Dyson, L Forsythe, S Vogt, S Yamaguchi, M Leake, M Mikolas, S Tuivailala, J Samardjiza, S Matz, R Gsellman
- Kiwis cut G Allen, R Martin, C Culberson, C Devenski, Z Littrell, TJ McFarland, J Waguespack, J Bruce, C Sadler
- Lumberjacks cut W Miley, S Kelly, D Betances, J James, S Duggar, B Holt
- Naturals cut T Milone, J Hughes, J Chavez, J Taylor, F Galvis, C Maybin, J Luplow, P Ervin, D Santana, R Zimmerman, B Swihart, C Hamels
- Sea Dogs cut J Smoak, M Thaiss, E Sogard, T Wolters, J Martinez, H Rondon, M Walden, C Smith, N Mazara
- Shamrocks cut J Teheran, J Zimmermann, J Nelson, J Eickhoff, E Santana, D Holland, L Malle, P Reyes, C Herrmann
- Sluggers cut J Chacin, S Oberg, A Pujols, B Dozier, J Mercer, H Pence, G Parra
- Team X cuts C Sabathia, B Hardy, C Bettis, D Murphy
- Tigers cut S Leon, E Nunez, J Rickard, M Duffy, A Chafin, A Suarez, C Richard, K Kela, L Cessa, J Pazos, T Chatwood, F Pena
- Triplets cut J Holder, Y Hirano, T Gott, C Gearrin, R Suarez, J Briceno, M Adams, J Hicks, L Martin, N Martini, N Vincent, A Sanchez
Note: Below are the drafted players on March 1-20, 2021
- Assassins draft A Knapp, A Slater, R Quinn, J Groshans, F Galvis, J Mathis, D Garneau, D O'Day, D Smyly, M. Meyer, T Scott, S Matz, A Miller, M Abel
- Condors draft R Arozarena, C Mullins II, M Stassi, T Ward, D Mendick, S Haggerty, T Shaw, J Arauz, A Bemboom, Z McKinstry, J Marmolejos, J Hahn, J Dunn, J Curtiss, C Sulser, C Shreve
- Cornfield draft A Kirk, P Leon, M Perez, O Colas, A Jackson, E Sogard, S Vogt, K Bubic, T Anderson, K Akin, A Lacy, L Webb, R Castellani, P Johnson, P Sandoval
- Dawgz draft H Kim, G Allen, J Jung, G Valera, T Swaggerty, I Diaz, J Fraley, A Alford, D Peterson, V Gonzalez, R Montero, J Hernandez, T Rogers
- Express draft A Santander, M Haniger, N Mazara, E Encarnacion, Y Tsutsugo, J Bauers, M Mikolas, P Fairbanks, H Harvey, C Smith, B Workman, M Moore, J Diaz, R Stripling, J Jimenez, S Oberg, G Gonzalez, D Betances
- Gadflies draft E. Rios, R Bannon, J Karinchak, M Perez, A Gomber, M Wisler, B Raley, N Turley, T. Alexander
- Goats draft P Evans, T Nido, R McBroom, N Gonzales, R Mauricio, Y Cespedes, E Ramirez, S Armstrong, J Hoyt
- Grizzlies draft S Huff, S Akiyama, A Stevenson, C Hernandez, J Hannah, T Freeman, D Dunning, T Antone, A Mills, T Houck, R Dobnak, L Gilbert, C Heuer, G Rodriguez, C Baragar, J Brubaker, G Soto, T Clarke, C Hill, C Kuhl, C Brogdon, C Seabold, S McClanahan
- Kiwis draft J Cronenworth, R Jeffers, M Brosseau, I Paredes, L Torrens, J Garcia, K Robinson, N Jones, G Crochet, T Rogers, A Morejon, E Paredes, B Wilson
- Lumberjacks draft D Waters, J Fuentes, J Gyorko, D Santana, C Maybin, J Canseco T Rosenthal, M Mayers, R Dolis, J Lindblom, E Fedde
- Naturals draft D Ruf, E Kratz, R Ruiz, C Wallach, J Davis, E Gonzalez, T Taylor, T Wade, H Kendrick, J Cisnero, D Tate, C Thielbar, K Zimmer, D Castano, R Smith, J Rodriguez
- Sea Dogs draft J Aguilar, D Stewart, D Fisher, C Arroyo, M Sierra, B Rooker, D Garcia, C Valdez, J Barria, D Kremer, G Cabrera
- Shamrocks draft J Walsh, M Dubon, T Wolters, L Campusano, S Langeliers, C Javier, A Slegers, M Foster, K Giles
- Sluggers draft D Moore, T Stephenson, R Chirinos, K Higashioka, G Greiner, G Heredia, R Urias, T Hatch, K Cody, B Garcia, N Margevicius
- Team X draft T Larnach, B Zimmer, J Harrison, J Montgomery, E Hernandez, K Finnegan, A Minter, Y Almonte
- Tigers draft W. Castro, T France, J Naylor, A Knizner, J Oliva, S Leon, A Baddoo, G Arias, T Marcano, S Heineman, A Allen, J Murphy, J Heim, T Matzek, D Bard, J Staumont, J Oviedo, J Woodford, R Helsley, J De Leon, D Rasmussen
- Triplets draft P Valaika, J Nottingham, P Gosselin, Z Veen, C Tromp, T Soderstrom, M Wieters, P Crow-Armstrong, A Cobb, J Romano, J McGee, T Cahill, B Smith, R Sherriff, E Hancock
- Vandals draft C Gallagher, L Guillorme, S Espinal, T Kemp, A Avila, D Williams, K Kim, J Fleming, T Eshelman
Note: Below were the traded players before April 1, 2021 deadline
- Goats trade K Hiura to Cornfield for C Frazier, 2022 4 (Cornfield)
- Shamrocks trade L Taveras to Condors for T Edman
- Goats trade G Stanton to Cornfield for A Verdugo
- Assassins trade S Doolittle, 2022 2 (Assassins) to Kiwis for J Diekman
- Cornfield trade L Voit, 2022 6 (Cornfield) to Triplets for J Downs, T Casas
- Lumberjacks trade Liam Hendricks to Assassins for J Bleday, J Groshans, M Meyer